thymine nucleotide

The radiation joins together neighboring thymine nucleotides, a type of DNA subunit, forming an unnatural chemical bond that distorts and disables the genetic molecule.

Since thymine nucleotides are precursors of DNA, not RNA, the prefix "deoxy" is often left out, i.e., deoxythymidine is often just called thymidine.

As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication.

This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP.

Open or initiated complexes were then probed by KMnO 4 footprinting, a reagent that cleaves the DNA preferentially in those positions in which the double helix is melted, single stranded thymine nucleotides being particularly sensitive.

The adaptive response is a form of direct DNA repair in E. coli that is initiated against alkylation, particularly methylation, of guanine or thymine nucleotides or phosphate groups on the sugar-phosphate backbone of DNA.

Comparing isolated cells from xeroderma patients with those of healthy people, Dr. Cleaver and others learned that in people with deadly sun sensitivity, cells failed to repair at least half of the distorting bonds that lashed thymine nucleotides together upon exposure to ultraviolet light.