thrombogenic

Also, they are the least thrombogenic of the artificial valves.

Many thrombogenic substances are located in the skin or in blood vessel walls.

For example, phosphorylcholine surface modified stents have exhibited reduced thrombogenic activity.

The thrombogenic hypothesis and its implications.

This arachidonic acid is then metabolized to form several inflammatory and thrombogenic molecules.

All materials are considered to be thrombogenic with the exception of the normal state of endothelial cells which line blood vessels.

Certain medical implants appear non-thrombogenic due to high flow rates of blood past the implant, but in reality all are thrombogenic to a degree.

A desirable characteristic of heart valve prostheses is that they are non or minimally thrombogenic.

There are many different such substances, which are called thrombogenic because they promote formation of thrombus (another name for a clot).

Examples of these thrombogenic substances are tissue factor, collagen, and von Willebrand factor.

Circulating microvesicles isolated from cardiac surgery patients were found to be thrombogenic both in vitro assays and in rats.

When the plaque ruptures suddenly, thrombogenic substances inside the plaque are exposed to blood, triggering the blood clotting process.

Platelet aggregation, thromboxane production and thrombogenic ratio in postmenopausal women consuming high oleic acid-sunflower oil or palmolein.

Ruptures of the fibrous cap expose thrombogenic material, such as collagen to the circulation and eventually induce thrombus formation in the lumen.

By inducing thrombogenic state through vasoconstriction of the microvasculature, tobacco influences blood flow, wound healing and the survival of pedicled flaps.

Non-thrombogenic - As natural heart valves are lined with an endothelium continuous with the endothelium lining the heart chambers they are not normally thrombogenic.

There have been many attempts made using surface treatments to create stents that are more biocompatible and less thrombogenic, in an attempt to reduce the need for extensive antiplatelet therapy.

Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels.

The Shiga-toxin-activated endothelial cells then become thrombogenic (clot-producing) by mechanism that is not fully understood, though they have been shown to induce the release of cytokines and chemokines that are implicated in platelet activation.

Also, epidemiological studies suggest that the Mediterranean diet is associated with lower coronary heart disease risk, especially through the reduction of blood pressures, body mass index, and levels of several thrombogenic factors [ 12 13 18 19 ] .

Even though it is present at only 5-10% the levels of α-antithrombin, due to its increased heparin affinity, it is thought that β-antithrombin is more important than α-antithrombin in controlling thrombogenic events resulting from tissue injury.

A thrombogenic implant will eventually be covered by a fibrous capsule, the thickness of this capsule can be considered one measure of thrombogenicity, and if extreme can lead to the failure of the implant.

They also review the history of the main hypotheses of atherogenesis: response to injury, lipid infiltration, monoclonal smooth muscle proliferation, thrombogenic 'encrustation', and autoimmunity, but they weave these together into what can fairly be called a consensus view.

As previously described in the section on corticosteroids, high-dose dexamethasone can complicate interpretation of clinical trials by worsening cardiopulmonary toxicity and deaths, especially in the context of thalidomide or lenalidomide, both of which are thrombogenic agents.

The extracellular matrix of the lesion breaks, usually at the shoulder of the fibrous cap that separates the lesion from the arterial lumen, where the exposed thrombogenic components of the plaque, mainly collagen will trigger thrombus formation.