thrombin time

Fibrinogen was measured by the thrombin time method.

Each dysfibrinogenemia is associated with slightly different effects on the thrombin time and on normal clotting.

The test is considered to be a replacement for thrombin time, and is used when heparin is present in the sample.

The thrombin time compares the rate of clot formation to that of a sample of normal pooled plasma.

Prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen tests should be performed.

Thrombin time (TT)

Thrombin time can be prolonged by heparin, fibrin degradation products, factor XIII deficiency, and fibrinogen deficiency or abnormality.

Amsterdam is a major defect, characterized by aggregation of fibrin monomers, prolonged thrombin time, and an inhibitory effect on normal clotting - but it is asymptomatic.

Detroit is a major defect, there is fibrinopeptide release, the thrombin time is prolonged, there is an inhibitory effect on normal clotting and there is abnormal bleeding.

Thus, the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged in these samples.

TCT or fibrinogen assay for final common pathway(THROMBIN TIME)

In both haemophilia A and B, there is spontaneous bleeding but a normal bleeding time, normal prothrombin time, normal thrombin time, but prolonged partial thromboplastin time.

Studies in animals and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time.

Other tests performed in any patient with bleeding problems are a complete blood count (especially platelet counts), APTT (activated partial thromboplastin time), prothrombin time, thrombin time and fibrinogen level.

The classical coagulation tests such as PT (prothrombin time), aPTT (activated partial thromboplastin time) or thrombin time are not very sensitive for hyperfibrinolysis, and influenced by numerous other variables.

The thrombin time (TT), also known as the thrombin clotting time (TCT) is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, after an excess of thrombin has been added.