Chromosome 16q22 has been shown to be involved in the genetic links of syringoma.

Milia-like this type of syringoma is typically smaller lesions that have a milky white center that can look like milia.

Familial some cases of syringoma exhibit a familial pattern in an autosomal dominant pattern of inheritance.

Specifically, diabetes mellitus is strongly associated with clear cell syringoma consisting of nests of clear cells containing glycogen.

Several systemic syndromes have also been associated with syringoma including diabetes mellitus, down syndrome, Brooke-Spiegler, and Nicolau-Balus.