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These are also covered by a layer of synovial cells.
There also is some evidence that it helps regulate synovial cell growth.
The target for the viral vector in this study, were the synovial cells.
The synovial cells may also use up nutrients so that the glucose level in the tissue is almost zero.
Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis.
In 1997 Buddy had his right hind leg amputated due to synovial cell sarcoma, a type of cancer that manifests near the joints.
Thus, some synovial cells remained responsive to IL-4- and anti-CD28-mediated signaling in the priming cultures.
It was canceled shortly after he announced that he was diagnosed with synovial cell sarcoma, a rare cancer in July 1996.
In July 1996, Urich announced he had been diagnosed with synovial cell sarcoma, a rare form of cancer that attacks soft tissue.
The attack starts in the cells lining the insides of the joints (synovial cells), causing inflammation (synovitis).
Normally functioning synovial cells produce TNFα and IL-1.
Supplementary material Supplementary Introduction Synovial cells play a central role in the pathophysiology of inflammatory arthritis.
The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells.
Synovial cells may also produce enzymes that can digest the cartilage surface, although it is not clear that these will damage cartilage with healthy cells.
However, the series' production company, Castle Rock Entertainment, cancelled the series after Urich was diagnosed with synovial cell sarcoma in July 1996.
Soft tissue sarcomas that more commonly spread to lymph nodes include synovial cell sarcomas, epithelioid sarcomas, and rhabdomyosarcomas.
K. kingae express type IV pili which allow for enhanced adhesion to respiratory epithelial and synovial cells and thus increased likelihood of colonization.
The inner layer is mainly composed of two cell types, specialized macrophages (macrophage-like synovial cells) and fibroblast-like synoviocytes, which are important in maintaing the internal joint homeostasis.
Much of our understanding of this biology has been derived from the study of primary fibroblast like synovial cells cultured from arthritic joints after arthroscopic biopsy or surgery.
The inflammatory process causes synovial cells to multiply, increasing collagen formation and fluid production within the bursa and reduction in the outside layer of lubrication (Ishii et al., 1997).
The series earned strong enough ratings to be picked up for a second season but shortly after the series was renewed, Urich announced he was had been diagnosed with synovial cell sarcoma.
Interestingly, the tenascin gene has been reported to be IL-1-inducible in synovial cells and chondrocytes, and its expression is enhanced in rheumatoid arthritis and OA [ 46, 47].
Stable genetic modification of primary synovial cells is an approach that may be useful in defining the roles that specific signaling pathways or inflammatory mediators play in the joint destruction associated with rheumatoid arthritis.
After withdrawing fluid from her knuckles for analysis, Dr. Herndon injected cultured synovial cells containing the gene into two knuckles, and control cells that did not contain the genes into two others.
It is well documented that elevated expression of IL-1β in the joint results in the activation of inflammatory and degradative programs in synovial cells, contributing to the progression of rheumatoid arthritis [ 2].