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They occur in the subpleural area and result from shearing forces at sites of transpleural adhesion.
Subpleural honeycomb cysts typically occur in several contiguous layers.
The emphysematous areas are subpleural in location and often surrounded by interlobular septa (hence the name).
Honeycomb cysts often predominate in the peripheral and subpleural lung regions regardless of their cause.
Adult worms occur in small air passages (bronchioles, bronchioli) and in the alveoli, even in the subpleural tissue.
Histological examination of the lung tissues may show acute serofibrinous to chronic fibrino-necrotic pleuropneumonia with neutrophilic inflammation in the alveoli, bronchioles, interstitial septae and subpleural connective tissue.
A Ghon focus is a primary lesion usually subpleural, often in the mid to upper zones, caused by mycobacterium bacilli (tuberculosis) developed in the lung of a nonimmune host (usually a child).
Tardieu's ecchymoses, subpleural spots of ecchymosis that follow the death of a newborn child by strangulation or suffocation, were first described by Tardieu in 1859, and were so named in his honor.
It is thought that asbestos fibres that reach the pleura induce subpleural fibroblasts and mesothelial cells to produce scar tissue and collagen deposition, resulting in subpleural thickening.
On high resolution computed tomography, airspace consolidation with air bronchograms is present in more than 90% of patients, often with a lower zone predominance A subpleural or peribronchiolar distribution is noted in up to 50% of patients.