stem cell factor , SCF (skrót)

Stem cell factor has been shown to interact with CD117.

Stem cell factor a cytokine.

Ancestim is a recombinant methionyl human stem cell factor, commonly known by the name StemGen.

The proliferation and self-renewal of these cells depend on stem cell factor (SCF).

It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell factor.

This gene encodes a transmembrane receptor for a growth factor termed stem cell factor (scf).

Amgen said it planned to file for marketing approval with the F.D.A. for stem cell factor within the next few months.

Activation of human mast cells through stem cell factor receptor (KIT) is associated with expression of bcl-2.

Steel factor receptor interacts chemically with steel factor or stem cell factor to relay chemical messages.

Stem cell factor (SCF) receptor (also called c-kit, see the article on gastrointestinal stromal tumor).

The c-kit ligand stem cell factor and anti-IgE promote expression of monocyte chemoattractant protein-1 in human lung mast cells.

Jun transcriptionally activates the promoters of SCF (stem cell factor) and CCL5.

It is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1).

Dr. Zsebo's group has produced stem cell factor, a substance that stimulates very primitive bone marrow cells to grow and develop into red and white blood cells.

Ligands that bind to RTKs include fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and stem cell factor.

It is an orally administered small molecule antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor receptors.

Briefly, eCSCs have been first identified through the expression of c-kit, the receptor of the stem cell factor and the absence of common hematopoietic markers, like CD45.

The company reported positive results in the final stage of clinical trials for stem cell factor, a possible $1 billion drug that would be used to increase blood cell production in cancer patients undergoing aggressive chemotherapy.

The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein.

The Kit proto-oncogene encodes a tyrosine kinase receptor whose ligand is a paracrine protein called stem cell factor (SCF), which is important in hematopoiesis (formation of cells in blood).

CD117 is a receptor tyrosine kinase type III, which binds to stem cell factor (a substance that causes certain types of cells to grow), also known as "steel factor" or "c-kit ligand".

These pathways include Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 and 3 kinases and c Kit the receptor for Stem cell factor. )

The two drugs - stem cell factor and granulocyte colony stimulating factor - stimulated the bone marrow to produce numerous stem cells, which entered the bloodstream, migrated to the damaged heart, and turned into new heart muscle.

Because stem cell factor acts so early in blood cell development, it could be of enormous benefit to patients whose bone marrows have been injured or have faltered, including chemotherapy patients, patients who had bone marrow transplants, and people with AIDS.

When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell.