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Spontaneous fractures are common and may be the first sign of the disease.
After the occurrence of first spontaneous fractures the damage is often already irreversible.
Up to eight million women have a severe form of this brittle-bone disease, causing many to experience spontaneous fractures, usually in the vertebrae of the back.
Longer annealing did not improve the crystalline quality, and annealing at higher temperatures resulted in spontaneous fracture of samples.
Spontaneous fractures in athletes generally requires a cessation of the cause, e.g., time off rowing, whilst maintaining cardiovascular fitness.
In the 11 years since her diagnosis, Katherine Mucciolo, of Floral Park, has suffered spontaneous fractures in bones throughout her body, until she wryly refers to herself as an eggshell.
Mautalen C, Gonzalez D, Blumenfeld EL, et al.: Spontaneous fractures of uninvolved bones in patients with Paget's disease during unduly prolonged treatment with disodium etidronate (EHDP).