sphingosine

The heads of glycolipids contain a sphingosine with attached to it.

A ceramide is composed of sphingosine and a fatty acid.

Finally, ceramide may be broken down by a ceramidase to form sphingosine.

The major sphingoid base of mammals is commonly referred to as sphingosine.

It is formed by the regulated phosphorylation of sphingosine.

Sphingosine is the main long-chain base present in ceramide.

Sphingosine is formed via degradation of sphingolipid in the lysosome.

The sphingosine and fatty acid can collectively be categorized as a ceramide.

Sphingosine may be phosphorylated to form sphingosine-1-phosphate.

Sphingosine is an amino alcohol that contains a long, unsaturated hydrocarbon chain.

This may be dephosphorylated to reform sphingosine.

Sphingosine can be released from ceramides, a process catalyzed by the enzyme ceramidase.

This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.

Also, the rate of removal of the accumulated sphinganine and sphingosine will affect the detoxification.

Glycosphingolipids are a subtype of glycolipids containing the amino alcohol sphingosine.

Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine.

In sphingomyelin the primary hydroxyl group of sphingosine is esterified to phosphoryl choline.

Structure of sphingosine.

Myriocin is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis.

Estimates conducted at physiological pH show that approximately 70% of sphingosine remains in membranes while the remaining 30% is water-soluble.

Fumonisin B2 inhibits sphingosine acyltransferase.

This reaction is a key step in the biosynthesis of sphingosine which is a precursor of many other sphingolipids.

Long-chain fatty acid amides of sphingosine occur frequently and some of them have known pharmacological activity.

The sphingosine backbone is O-linked to a (usually) charged head group such as ethanolamine, serine, or choline.

Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate, are lipid second messengers involved in diverse cellular processes.