solid-phase synthesis

Second, the protecting group must be able to withstand the conditions of solid-phase synthesis.

In the basic method of solid-phase synthesis, building blocks that have two function groups are used.

It has been replaced in most labs by solid-phase synthesis (see below).

Overall, this is a powerful method for solid-phase synthesis of β-mannosides, which has great potential to be further extended, was established.

Solid-phase synthesis is the most common technique for peptide synthesis.

These orthogonally-protected cysteines are incorporated during the solid-phase synthesis of the peptide.

Hence, DIC is more often used in solid-phase synthesis.

In one solid-phase synthesis application, the amine is covalently attached to Wang resin.

The Angeli-Rimini reaction has recently been applied in solid-phase synthesis with the sulfonamide covelently linked to a polystyrene solid support.

Traditionally, solid-phase synthesis has relied on polystyrene-based resins for the synthesis of all kinds of peptides.

Recently, an efficient stepwise solid-phase synthesis of RANTES (24-91) was published.

Marvin Caruthers at the University of Colorado determined how to synthesize small oligonucleotides by solid-phase synthesis using the phosphoramidite method.

The strategy for the solid-phase synthesis of cyclic peptides in not limited to attachment through Asp, Glu or Lys side chains.

In contrast to organic solid-phase synthesis and peptide synthesis, the synthesis of oligonucleotides proceeds best on non-swellable or low-swellable solid supports.

And the most widely used method in publication is cleavable disulfide linkages through total stepwise solid-phase synthesis or solution-phase or solid-phase fragment coupling.

The earliest demonstrations of DNA polyhedra were very work-intensive, requiring multiple ligations and solid-phase synthesis steps to create catenated polyhedra.

Abgent specializes in FMOC solid-phase synthesis of peptides using pseudoproline to improve the quality of synthetic peptides.

A DNA library for any protein or small peptide of interest can be synthesized by solid-phase synthesis followed by PCR amplification.

Pseudoproline (also pseudo-proline, ψ-Pro) derivatives are artificially created dipeptides to minimize aggregation during FMOC solid-phase synthesis of peptides.

DNA has better cost-effectiveness and DNA can be made with longer sequence length and can be made with higher purity in Solid-phase synthesis.

Merrifield resin is named after its inventor, Robert Bruce Merrifield (1984 winner of the Nobel Prize in Chemistry), and used in Solid-phase synthesis.

In solid-phase synthesis, an oligonucleotide being assembled is covalently bound, via its 3'-terminal hydroxy group, to a solid support material and remains attached to it over the entire course of the chain assembly.

This contribution that is mainly based on the work at Eindhoven also consists of new insights in solid-phase synthesis, B-Z transition, and methyl transfer reactions connected with replicational and transcriptional silencing.

Alternatively, a solid-phase synthesis of strontium boride can be carried out by reacting two moles of strontium carbonate with three moles of boron carbide and one mole of carbon inside a vacuum furnace.

The protecting groups in solid-phase synthesis with regard to the reaction conditions such as reaction time, temperature and reagents can be standardized so that they are carried out by a machine, while yields of well over 99% can be achieved.