selective inhibition

Selective inhibition of vitamin B12 absorption by para-aminosalicylic acid.

C-domain selective inhibition could possibly result in specialized control of blood pressure with less vasodilator-related adverse effects.

Although both enzymes act basically in the same fashion, selective inhibition can make a difference in side-effects.

Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias.

Current efforts, however, are directed to the development of new drugs with selective inhibition or receptor blockade of a single mediator.

This results in selective inhibition of the strand-transfer reaction, with no significant effect on the 3'-processing reaction.

This selective inhibition (without inhibiting other glycosaminoglycans) may prove useful in preventing metastasis of malignant tumor cells.

After thalidomide's selective inhibition of TNF-α had been reported a renewed effort was put in thalidomide's clinical development.

Farinomalein has shown potent and selective inhibition (0.15-5 μg/disk) against eight isolates of plant pathogenic Phytophthora sojae.

Piclamilast functions through the selective inhibition of the four PDE4 isoforms (PDE4A-D).

Jimi, E., et al., Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo.

Stauprimide was first published in 1994 as part of an extensive structure-activity investigation to improve the selective inhibition of protein kinase C as a potential antitumor agent.

Such a restoration of cellular redox by berberine is mediated by its selective inhibition of gp91phox expression and enhancement of SOD activity.

Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission.

A para-sulfamoylphenyl at position 1 of the pyrazole was found to have a higher potency for COX-2 selective inhibition than a para-methoxyphenyl (see structures 1 and 2, below).

The antifungal activity of pterulone is based on selective inhibition of the NADH dehydrogenase enzyme of the electron transport chain.

The most significant difference between the isoenzymes, which allows for selective inhibition, is the substitution of isoleucine at position 523 in COX-1 with valine in COX-2.

There are marked differences among NSAIDs in their selective inhibition of the two subtypes of cyclo-oxygenase, COX-1 and COX-2 .

It suppresses CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription.

Saliou C, Rihn B, Cillard J, et al.: Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2.

Evers B, Drost R, Schut E, et al.: Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

It is now believed that this selective inhibition of the enzyme COX-3 in the brain and spinal cord explains the ability of artemether in relieving pain and reducing fever which produced by malaria.

May, M.J., et al., Selective inhibition of NF-kappaB activ ation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.

Selective inhibition of rat lung cyclic AMP phosphodiesterase and cyclic GMP phosphodiesterase by cyclic nucleotides and their analogues and various drugs.

MZB exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides.