sarcomatoid

Also called sarcomatoid carcinoma.

The other types begin in spindle-shaped cells called sarcomatoid cells or are a mixture of both cell types.

Herbert Blau, 87, American theater director, scholar and theorist, sarcomatoid carcinoma of the chest.

The epithelioid histology responds better to treatment and has a survival advantage over sarcomatoid histology.

Finally, some rare forms of breast cancer (e.g. sarcomatoid carcinoma, inflammatory carcinoma) have a poor prognosis.

Two cases of MTSCC with sarcomatoid change have been described, one with widespread metastasis to distant organs, including lung and bone.

After Terri's surgery, Paul phoned with the lowdown: the surgeons had discovered a patch of aggressive "sarcomatoid" cells, which meant Terri's prognosis was bleak.

At nephrectomy his liver was found to be pale and firm and enlarged.The mass was found to be a sarcomatoid renal tumour with an adrenal metastasis.

Rarely, spermatocytic seminomas may show sarcomatoid differentiation, most commonly as undifferentiated spindled cells intermingled within the typical-appearing spermatocytic seminoma cells.

While the 4th revision ("WHO-2004") retained the same grouping of lesions as the 3rd revision, the name of the major taxon was shortened to "sarcomatoid carcinomas".

CD10 differentiates CD10 atypical fibroxanthoma from CD10 spindle cell melanoma and sarcomatoid squamous cell carcinoma.

Histological variants of lung cancer classified as sarcomatoid carcinoma include pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma.

Sarcomatoid carcinomas are unique among lung carcinomas in that, although they are considered carcinomas, they contain cytological and tissue architectural features that are usually characteristic of sarcoma.

Sarcomatoid carcinoma is a relatively uncommon form of cancer whose malignant cells have histological, cytological, or molecular properties of both epithelial tumors ("carcinoma") and mesenchymal tumors ("sarcoma").

A spindled component is characteristic of MTSCC, but the presence of significant pleomorphism with prominent nucleoli and mitotic activity, and necrosis should raise concern for a sarcomatoid change.

Sarcomatoid changes (morphology and patterns of IHC that mimic sarcoma, spindle cells) can be observed within any RCC subtype and are associated with more aggressive clinical course and worse prognosis.

The researchers found DNA changes specific to type 1 and 2 papillary RCC, sarcomatoid RCC, and clear cell RCC with and without a mutation of the VHL gene.

Negative prognostic factors include sarcomatoid or biphasic histology, high platelet counts (above 400,000), age over 50 years, white blood cell counts above 15.5, low glucose levels in the pleural fluid, low albumin levels, and high fibrinogen levels.

However, as certain types of tumors (such as sarcomatoid mesothelioma) do not release SMRP, the FDA recommends that doctors use the MESOMARK assay in conjunction with other tests to ensure an accurate mesothelioma diagnosis.

Papillary renal cell carcinoma: MTSCC may have some morphologic similarities to the more common papillary renal cell carcinoma (papillary RCC), particularly the basophilic tumors (type 1 papillary RCC) with prominent solid growth pattern with sarcomatoid transformation.