Symptoms typically improve after restoration of weight, except when reversed peristalsis persists, or if regained fat refuses to accumulate within the mesenteric angle.

Reversed peristalsis has been shown to respond to duodenal circular drainage-a complex and invasive open surgical procedure originally implemented and performed in China.

However, the reason for the persistance of gastrointestinal symptoms even after surgical correction has been recently traced to the remaining prominence of reversed peristalsis in contrast to direct peristalsis.

The possible persistence of symptoms after surgical bypass can be traced to the remaining prominence of reversed peristalsis in contrast to direct peristalsis, although the precipitating factor (the duodenal compression) has been bypassed or relieved.

Symptoms include early satiety, nausea, vomiting, extreme "stabbing" postprandial abdominal pain (due to both the duodenal compression and the compensatory reversed peristalsis), abdominal distention/distortion, eructation, external hypersensitivity or tenderness of the abdominal area, and severe malnutrition accompanying spontaneous wasting.