His thesis was titled "Intermittent and Remittent Fevers".

Systemic symptoms include low grade remittent fever, chills, night sweats, appetite loss, weight loss, easy fatiguability, and production of sputum that starts out mucoid but changes to purulent.

In all instances where life is in danger from a return of a paroxysm of intermittent or remittent fever, the patient can be rescued from immediate danger by giving Quinine in doses sufficient to prevent a return of the paroxysm.