The three most common serious conditions that can affect Heelers are Collie eye anomaly, Primary lens luxation and Persistent pupillary membranes.

In the PBGV Club of America 2000 survey, the most common diseases reported by owners of 640 dogs were persistent pupillary membranes, recurrent ear infections, hypothyroidism, neck pain, and epilepsy.

Problems only occasionally found include cardiomyopathy, allergies, vaginal hyperplasia, cruciate ligament rupture, hypothyroidism, OCD, entropion, progressive retinal atrophy (PRA), and persistent pupillary membranes (PPM).