Some users have also reported dissociative properties uncharacteristic of other psychedelic phenethylamines.

Many have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense.

Many users report that 2C-C is gentler and more sedating than other closely related psychedelic phenethylamines.

A series of psychedelic phenethylamines:

The activity of Ψ-DOM (and Ψ-2C-T-4) demonstrates that the two methoxy groups on the psychedelic phenethylamines are not strictly limited to the 2,5 positions on the phenyl ring.

While N-benzyl substitution of psychedelic phenethylamines often results in potent 5-HT agonists, N-benzyl tryptamines show much lower efficacy and are either very weak partial agonists or antagonists at 5-HT.

The euphoriant effect shared by several other psychedelic phenethylamines seems only to have been reported relatively rarely by users of 2C-E; the compound has been described as "difficult" by its users, including its inventor Shulgin: