Proxymetacaine has been found to have the best tolerance.

Proxymetacaine is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%.

Proxymetacaine is for topical ophthalmic use only, and it is specifically not intended for injection.

Because the probe makes contact with the cornea, a topical anesthetic, such as proxymetacaine, is introduced on to the surface of the eye in the form of an eye drop.

A spokeswoman for the company said: "Bausch and Lomb is conducting a voluntary recall of a single lot of proxymetacaine 0.5 per cent Minims Eye Drops Solution.

When used excessively, oxybuprocaine like any other topical anesthetic used in the eye and on mucous membranes (like for example tetracaine, proxymetacaine and proparacaine) can cause irritation, hypersensitivity, anaphylaxis, irreversible corneal damage and even complete destruction of the cornea.

Proxymetacaine is believed to act as an antagonist on voltage-gated sodium channels to affect the permeability of neuronal membranes; how this inhibits pain sensations and the exact mechanism of action of proxymetacaine are, however, unknown.

Proxymetacaine (INN) or proparacaine (USAN) is a topical anesthetic drug of the aminoester group.

One drop of 0.5% proparacaine hydrochloride (Alcon, Ft Worth, TX) was instilled into each eye and the corneas were deepithelized with the use of a rotating brush.

The 2007 procedure to remove an adult worm from a male Gabonian immigrant employed proparacaine and povidone-iodine drops, a wire eyelid speculum, and 0.5ml 2% lidocaine with epinephrine 1:100,000, injected superiorly.

When used excessively, oxybuprocaine like any other topical anesthetic used in the eye and on mucous membranes (like for example tetracaine, proxymetacaine and proparacaine) can cause irritation, hypersensitivity, anaphylaxis, irreversible corneal damage and even complete destruction of the cornea.