proliferation zone
proliferative zone

The average number of labelled cells (x) per 50 hemicrypts in the proliferation zone was used to extrapolate to the total crypt size.

Human gastric mucosa is a complex proliferation model when compared with colorectal mucosa, because of the convolution of the crypts and because the proliferation zone is located in the middle or upper part of the crypt, possibly producing bidirectional movement of maturing cells.

The proliferative zone, however, was expanded in the distal colon of the higher fibre diet fed rats.

One, ASPM, is active in the proliferative zone where neurons are born.

Precursor cells in this "proliferative zone" give birth to neurons that migrate up and out into the cortex, forming its layers.

Scoring was performed for each cell along the crypt column to a point immediately beyond the proliferative zone where crypt continuity was lost.

They found that supplementation reduced the total cell proliferation although in contrast with our results, vitamin C did not change the upward shift of the proliferative zone.

Neural precursors are generated in proliferative zones, before migrating to directed locations where they undergo maturation and become functional neurons.

In the gastric body crypts, intense labelling occurred in the proliferative zone, with cell migration up the crypts taking place over 96 hours.

In addition glands have aberrant proliferative control evidenced by the observation of the characteristic extended or abnormal proliferative zones associated with increased growth factor expression.

Subjects with adenomatous polyps and cancer have an increased cell proliferation and a shift of the proliferative zone towards the apex of the crypt.

Each of these areas contains proliferative zones where neurons and glial cells are generated; the resulting cells then migrate, sometimes for long distances, to their final positions.

Our data confirm an upward shift of the proliferative zone in the patients with adenomatous colorectal polyps (which are themselves associated with an increased tendency to develop colon cancer).

Moreover we, and others, have also shown that the density of EGF receptors is maximal in the basal layer of the squamous oesophagus, which is the proliferative zone.

In one of the most startling examples of brain deformity, neurons explode out of the proliferative zone like lava, flowing to form a thick mass instead of an orderly, folded up cortex.

It is generally accepted, however, that hyperproliferation of the colorectal mucosa with a shift of the proliferative zone to the upper portion of the crypt is the first step of the sequence.

These factors may have led to a decrease in the exposure of the colonic mucosa to carcinogens and may have protected the colon and negated any effect of the modest increases in the proliferative zone in the distal colon.

A mnemonic for remembering the names of the epiphyseal plate growth zones is " Real People Have Career Options," standing for: Resting zone, Proliferative zone, Hypertrophic cartilage zone, Calcified cartilage zone, Ossification zone.

Another mechanism, poorly understood until recently, is the increase in the proliferative zone length by the exaggeraton of the folds in the basal epithelium (papillae formation) to enable an increased proliferative compartment to generate and maintain the same size of superficial (differentiated) epithelial compartment.

In this regard one of the early 'adaptive' responses to increased cell loss in reflux oesophagitis is an increase in the proliferative zone height to maintain or even, in some individuals, increase epithelial thickness by trophic stimulation of epidermal growth factor (EGF) contained in the adjacent endothelium.

The oesophageal stem cells in the proliferative zone, as a rule, proliferate more slowly and do not migrate to maintain their 'niche' in the epithelial/ mesenchyme interface whereas their progeny (the transit amplifying cells) divide and migrate sideways, upwards and, during inflammation, probably downwards also into deeper layers.