While survival is possible, mortality from severe or profound hypothermia remains high despite optimal treatment.

"Profound hypothermia and circulatory arrest with skull base approaches for treatment of complex posterior circulation aneurysms."

Body temperature Hypothermia causes progressive slowing of brain activity at core temperatures below 35 C. Complete electrical silence occurs with profound hypothermia (7-20 c) [ 22].

In 1969 he brought the technique of profound hypothermia and circulatory arrest into the limelight as a practical method for dealing with major corrective surgery in neonates with congenital heart disease, in so doing further establishing Greenlane Hospital on the international stage.