Measurements of cell proliferation can be used as biomarkers of preneoplastic change.

Hyperplasia is a common preneoplastic response to stimulus.

These lesions are called precancers, premalignancies, preneoplastic lesions, incipient cancers, intraepithelial neoplasias, and preinvasive cancers.

Diffuse hyperplastic perilobar nephroblastomatosis is defined as nephroblastomatosis forming a thick rind around one or both kidneys and is considered a preneoplastic condition.

Surveillance of Barrett esophagus involves the use of tests to identify preneoplastic changes or curable neoplasms in patients who are known to have Barrett esophagus.

Although the prevalence of prostate cancer and preneoplastic lesions found at autopsy steadily increases for each decade of age, most of these lesions remain clinically undetected.

Human clinical material for biomarker analysis in primary chemoprevention studies is also likely to comprise normal and initiated, at-risk epithelium with some early preneoplastic changes, but without evidence of major neoplastic change.

Oral squamous cell carcinomas are often preceded by oral preneoplastic lesions, which are often present as visible alterations of the mucosal surface and include leukoplakia and erythroplakia.

Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism.

It is developing keys for the identification of genes which show an significant increase or decrease in their expression level of fibrosis in preneoplastic and neoplastic lesions in the liver.

Lecomte T, Cellier C, Meatchi T, et al.: Chromoendoscopic colonoscopy for detecting preneoplastic lesions in hereditary nonpolyposis colorectal cancer syndrome.

Tabor MP, Brakenhoff RH, Ruijter-Schippers HJ, et al.: Multiple head and neck tumors frequently originate from a single preneoplastic lesion.

Subgroups at high risk of developing a defined type of tumor, for example families with hereditary cancer or individuals with preneoplastic lesions, are the natural candidates for immunoprevention of non-infectious tumors.

For a few strains oral administration effectively reduced DNA adduct formation, ameliorated DNA damage and prevented putative preneoplastic lesions such as aberrant crypt foci induced by chemical carcinogens in the gastrointestinal tract.

These findings are consistent with normal appearing, preneoplastic hepatocytes forming clonal masses in the liver because M6P/IGF2R haploid insufficiency affords them with a selective growth and/or survival advantage relative to normal hepatocytes [ 46 ] .

Sun, Y., Hegamyer, G. and Colburn, N. H. (1994) Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3.

Topics include descriptive, analytical, biochemical, and molecular epidemiology, the use of biomarkers to study the neoplastic and preneoplastic processes in humans, chemoprevention and other types of prevention trials, and the role of behavioral factors in cancer etiology and prevention.

In Xenopus AGR2 plays a role in cement gland differentiation, however in human cancer cell lines high levels of AGR2 correlate with downregulation of the p53 response and AGR2 levels are elevated in the preneoplastic tissue Barrett's oesophagus.

Since the focus of the present study was on TGF-β expression changes in the preneoplastic gland, staining of the tumors was not scored for the analysis, but in the two cases present, the staining did not differ significantly from that of the surrounding normal-appearing ducts (not shown).

In a study evaluating the genotoxic and carcinogenic risks associated with the consumption of repeatedly heated coconut oil (RCO), one of the commonly consumed cooking and frying medium, it was concluded that dietary consumption of RCO can cause a genotoxic and preneoplastic change in the liver.