The compositions were variable and depended upon the leachant and subsequent precipitating conditions.

Other precipitating conditions include a heart attack, an enlarged heart and infections of the heart muscle or surrounding tissue.

Hypopituitarism, neurogenic diabetes insipidus, tertiary hypothyroidism, and developmental disorders are examples of precipitating conditions caused by hypothalamic disease.

The extent of the necrosis is a major determinant of the prognosis, which in turn is dependent on the duration of ischemia, duration of oliguria, and the severity of the precipitating conditions.