potassium tert-butoxide

It is similar in reactivity to the more common potassium tert-butoxide.

Potassium tert-butoxide, used as a base for organic elimination reactions.

Because of this, potassium tert-butoxide is one example of a better reagent to use.

Schlosser's base is a superbase produced by treating butyllithium with potassium tert-butoxide.

A notable reagent is Schlosser's base, a mixture of n-butyllithium and potassium tert-butoxide.

Commonly, the mixture is formed by combining n-butyllithium and potassium tert-butoxide in a one-to-one ratio.

For this purpose, pyridine derivatives can be eliminated with good leaving groups using strong bases such as sodium and potassium tert-butoxide.

Examples include sodium tert-butoxide and potassium tert-butoxide.

In the Woodward modification, Woodward substituted potassium tert-butoxide for the aluminum alkoxide.

One such system for reduction of ketones consists of tert-butanol and potassium tert-butoxide and very high temperatures.

Arduengo and co-workers have used potassium tert-butoxide without the addition of a metal hydride to deprotonate precursor salts.

Potassium tert-butoxide is the chemical compound with the formula K(CH)CO.

Potassium ethoxide is used as a strong base, similar to sodium and potassium methoxides, and potassium tert-butoxide.

In one study the 1,7-ditrans isomer is generated at low temperatures in THF by dehydrohalogenation of a hexabromocyclododecane with potassium tert-butoxide.

The Schlosser base (or Lochmann-Schlosser base), the combination of n-butyllithium and potassium tert-butoxide, is a commonly used superbase.

Then mesylation with pyridine and TsOH gives 3, and elimination with potassium tert-butoxide in tert-butanol gives 4.

This finding was confirmed in another study with a slightly modified NHC using DBU as the base instead of potassium tert-butoxide (Scheme 3).

A similar reaction by asymmetric synthesis organocatalyzed by a protected cysteine and potassium tert-butoxide afforded a cyclohexene with 95% enantiomeric excess:

The enolate was formed by the reaction of ketone 47 with potassium tert-butoxide, and subsequent reaction with phenylseleninic anhydride followed by acylation gave α-acylketone 49.

The Seyferth-Gilbert homologation is a chemical reaction of an aryl ketone 1 (or aldehyde) with dimethyl (diazomethyl)phosphonate 2 and potassium tert-butoxide to give substituted alkynes 3.

This compound is the double Diels-Alder adduct of the diiodide-cyclophane 3.1 and anthracene 3.3 by reaction in presence of potassium tert-butoxide in refluxing dibutyl ether through a di-aryne intermediate 3.2.

Potassium tert-butoxide crystallises from THF/pentane at 20 C as [tBuOK tBuOH], which consists of infinite one-dimensional chains linked by hydrogen bonding.

This ketone was depronated with potassium tert-butoxide in tetrahydrofuran at low temperature and further oxidized by reaction with benzeneseleninic anhydride to give α-hydroxyketone 39, which was subsequently acylated to give α-acetoxyketone 40.

In the example shown, even a sterically hindered ketone such as camphor can be successfully converted to its methylene derivative by heating with methyltriphenylphosphonium bromide and potassium tert-butoxide, which generate the Wittig reagent in situ.

For example, Wooward used potassium tert-butoxide and benzophenone for the oxidation of quinine to quininone, as the traditional aluminum catalytic system failed to oxidize quinine due to the complex formed by coordination of the Lewis-basic nitrogen to the aluminum centre.