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This protein allows for many changes both presynaptically and postsynaptically.
They can exist either presynaptically or postsynaptically depending upon cell types.
Postsynaptically, electrocytes work much like muscle cells.
The receptor sits in the membrane of its neuron, usually localized at a synapse, postsynaptically.
Postsynaptically, innervation causes dendritic spines to remodel by as much as 30% over a period of seconds.
If the receptor is located postsynaptically then when activated the receptor causes Inhibitory postsynaptic potential.
While some drugs act presynaptically (such as botulinum toxin and tetanus toxin), those of current clinical importance work postsynaptically.
Postsynaptically, F-actin can be found in the postsynaptic density zone (PSDZ) and throughout the spine head and neck.
For induction to occur postsynaptically and be partially expressed presynaptically, a message must travel from the postsynaptic cell to the presynaptic cell in a retrograde (reverse) direction.
High levels of protein-tyrosine kinases and phosphatases and their substrates at synapses, both presynaptically and postsynaptically, suggest that tyrosine phosphorylation may regulate synaptic transmission.
Were LTP entirely induced and expressed postsynaptically, there would be no need for the postsynaptic cell to communicate with the presynaptic cell following LTP induction.
Retrograde signaling is a hypothesis that attempts to explain that, while LTP is induced and expressed postsynaptically, some evidence suggests that it is expressed presynaptically as well.
Postsynaptically, actin filaments traffic AMPA receptors to the PSDZ, while also providing scaffolding for plasticity products such as CAMKII.
Liao D, Hessler NA, Malinow (1995) Activation of postsynaptically silent synapses during paring-induced LTP in CA1 region of hippocampal slice.
This is accomplished either by acting presynaptically via the inhibition of acetylcholine (ACh) synthesis or release or by acting postsynaptically at the acetylcholine receptors of the motor nerve end-plate.
In theory, the excitatory effects of reducing GABA release and inhibitory effects of reducing glutamate release should cancel each other out with no net effect postsynaptically; however, it is clear that cannabinoids do affect neuronal activity.
The retrograde signaling hypothesis proposes that during the early stages of LTP expression, the postsynaptic cell "sends a message" to the presynaptic cell to notify it that an LTP-inducing stimulus has been received postsynaptically.
When CaMKII is infused in postsynaptically in the hippocampal slices and intracellular perfusion or viral expression, there is a two- to threefold increase in the response of the synapse to glutamate and other chemical signals.
Such postsynaptic models are unparsimonious, and so if any given starburst amacrine cells conveys motion information to retinal ganglion cells then any computing of 'local' direction selectivity postsynaptically by retinal ganglion cells is redundant and dysfunctional.