pleiotropy

Could there be a similar pleiotropy between madness and mathematics?

In addition to that, pleiotropy is under strong stabilizing selection.

This may occur as a result of pleiotropy or gene linkage.

Pleiotropy means one gene that has two or more effects on the phenotype.

Indeed, pleiotropy is one of the most common traits possessed by genes overall.

Surprisingly little pleiotropy is needed to reduce the degree of senescence substantially.

Based on antagonistic pleiotropy, Rose expected that this would surely reduce their fertility.

This is an example of antagonistic pleiotropy being an explanation for senescence.

But mutational theories of ageing can also involve pleiotropy (for example see Box 2).

Genetic pleiotropy refers to genes that have multiple effects.

Williams (1957) proposed his own theory, called antagonistic pleiotropy.

With pleiotropy a hypothetical gene would be selected by natural selection or other related mechanisms.

But it may be simply a by-product of genes selected for other functions (pleiotropy).

Pleiotropy has significance for the theory of evolution.

In antagonistic pleiotropy, genes carry effects that are both beneficial and detrimental.

Antagonistic pleiotropy has been identified both in model organisms and in humans.

This was another setback for pleiotropy theory, though Rose maintains it may be an experimental artifact.

Like with pleiotropy, traits could reach fixation in a population as a by-product of selection for another.

In addition, the overall benefit of alleles is cut down significantly (by about half) by pleiotropy.

Genetic correlations and hence correlated responses to selection are most often caused by pleiotropy.

Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits.

In antagonistic pleiotropy, one of these effects is beneficial and another is detrimental.

This is in contrast to pleiotropy, where a single gene may cause multiple phenotypic expressions or disorders.

We are also actively pursuing transient metabolic controllers to minimize pleiotropy.

Other well-known examples of pleiotropy include albinism and sickle-cell anemia.