In 1979 he published a well-known paper on the structure of platelet-activating factor and its relationship with histamine.

The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor.

Interestingly, cPLA may also release the lysophospholipid that becomes platelet-activating factor.

Mast cell granules contain histamine, heparin, platelet-activating factor, and other substances.

PAF acetylhydrolase is an enzyme that catabolizes platelet-activating factor.

Several molecular species of platelet-activating factor that vary in the length of the O-alkyl side-chain have been identified.

Another phospholipase A 2 -derived lipid, platelet-activating factor, also has some of the properties expected of a retrograde messenger.

Hyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergic response.

Then, mast cells release histamine, which then leads to the release of cytokines, prostaglandins, and platelet-activating factor.

It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies.

It is responsible for encoding the alpha subunit of the intracellular Ib isoform of platelet-activating factor acetylhydrolase.

Granule contents of basophils are abundant with histamine, heparin, chondroitin sulfate, peroxidase, platelet-activating factor, and other substances.

More recently, the degranulating action of platelet-activating factor has been demonstrated (Chignard et al, 1979; McManus et al, 1979).

PAF-AH inactivates platelet-activating factor, a phospholipid that plays a role in the inflammation seen in sepsis.

An intriguing possibility is that AKXD28 and D2 mice have differing responses to platelet-activating factor (PAF).

Platelet-activating factor acetylhydrolase 2, cytoplasmic is an enzyme that in humans is encoded by the PAFAH2 gene.

This included the finding that seizure-induced platelet-activating factor production activates gene expression, as well as a new neuroprotection site, the PAF receptor.

Disintegrins act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and collagen.

Platelet-activating factor (PAF) is an ether lipid which has an acetyl group instead of an acyl chain at the second position (SN-2).

The platelet-activating factor receptor is a G-protein coupled receptor which binds platelet-activating factor.

Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling.

Ginkgolides, especially ginkgolide B, are potent antagonists against platelet-activating factor, and thus may be useful in protection and prevention of thrombus, endotoxic shock, and from myocardial ischeamia.

The enzymes within this family are lipoprotein-associated phospholipase A2, cytoplasmic platelet-activating factor acetylhydrolase 2, and platelet-activating factor acetylhydrolase 1b.

The end result includes activation of arachidonic acid pathway and production of thromboxane A, production of IL-8, platelet-activating factor, and several intercellular adhesion molecules.

Phosphorylcholine is part of platelet-activating factor; the phospholipid phosphatidylcholine as well as sphingomyelin, the only phospholipid of the membrane that is not built with a glycerol backbone.

Until now, however, only a few data pointed to the production of platelet activating factor in physiological processes.

In this study, we found platelet activating factor in four of 13 normal subjects.

Extraction of platelet activating factor was performed during 10 hours at -4 C using a 'roller'.

There are, however, some differences in the action of caerulein and platelet activating factor on the pancreas.

Therefore we suggest that platelet activating factor should be considered as a global mucosal activity marker.

Several hormones may stimulate platelet activating factor biosynthesis in vitro.

The efficiency of this procedure averaged 80% using (3 H) platelet activating factor as internal standard.

Thus, the role of platelet activating factor should be interpreted considering both H pylori and acid.

About 24 hours before assay the sample was placed in 80% ethanol to extract platelet activating factor from the tissue.

The dried residues were then acetylated as described above and platelet activating factor was assayed.

So far, the cellular origin of platelet activating factor from colonic mucosa remains unclear.

Firstly, gastrin would exert a direct negative effect on platelet activating factor synthesis.

Such a mechanism seems unlikely because platelet activating factor precursors increase under pentagastrin infusion.

This hypothesis deserves further study as platelet activating factor metabolism in the stomach lumen is unknown.

The platelet activating factor is capable of producing some of the effects of allergy.

Platelet activating factor decreases with prednisolone therapy and might return to normal concentrations in quiescent patients.

Platelet activating factor was extracted from biopsies using ethanolic extraction as previously reported by us and others.

Assay for platelet activating factor - Washed rabbit platelets were prepared as previously described.

The possibility that platelet activating factor may be involved in Crohn's disease has been suggested by Kald et al.

In addition platelet activating factor was also found, although to a lesser extent in normal, uninflamed mucosa.

The role of platelet activating factor blocker in the treatment of inflammatory bowel disease deserves investigation.

The significance of platelet activating factor in the gastric juice of healthy humans is still difficult to analyse.

We can not exclude the possibility, however, of abnormal metabolism of platelet activating factor in four of them.

Clearly, whether low gastric platelet activating factor concentration in 30% normal subjects should be considered as physiological or pathophysiological needs further investigation.

Twenty four hours before platelet activating factor assay, biopsy specimens in 80% ethanol were cut into small pieces (less than 1 mg).