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Some evolutionary biologists believe that the vertebrate pineal cells share a common evolutionary ancestor with retinal cells.
The pineoblastoma is histologically similar to the medulloblastoma; however, according to the WHO, its histogenesis is linked to a pineal cell, the pineocyte.
Most tumors of the pineal region are either germinomas or pineal cell tumors, and are tumors of adolescents and young adults.
One compound class which containing a rhodanine scaffold has shown low micromolar competitive inhibition against acetyl-CoA and proved to be effective in blocking melatonin production in pineal cells.
The principal cell type of the pineal is the pinealocyte sensu stricto.
The nucleus of a Type 2 pinealocyte contains many infoldings which contain large amounts of rough endoplasmic reticulum and ribosomes.
In the pinealocyte cells of the pineal gland, serotonin N-acetyltransferase is involved in the conversion of serotonin to melatonin.