pigmented villonodular synovitis

While pigmented villonodular synovitis can occur in both pediatric and geriatric patients, it is more common with ages 20-50.

His diagnosis was "pigmented villonodular synovitis".

Pigmented villonodular synovitis (PVNS)

Pigmented villonodular synovitis (PVNS) is a joint disease characterized by inflammation and overgrowth of the joint lining.

Pigmented villonodular synovitis, described distinctly in 1941 by Charles J. Sutro, L. Lichtenstein, and H.L. Jafe, comes in two forms: localized and diffuse.

In general, pigmented villonodular synovitis often manifests initially as sudden onset, unexplained joint swelling and pain; the joint swelling is disproportionate to the amount of pain the patient feels at first.

Radiation therapy can also be used in non-malignant conditions, such as the treatment of trigeminal neuralgia, severe thyroid eye disease, pterygium, pigmented villonodular synovitis, and prevention of keloid scar growth, vascular restenosis, and heterotopic ossification.

This led to the discovery of cellular and molecular mechanisms of pathological bone resorption associated with primary and secondary bone tumours, particularly breast cancer metastasis, Ewing sarcoma and giant cell-rich lesions such as giant cell tumour of bone and pigmented villonodular synovitis.