Piecemeal necrosis generally refers to a necrosis that occurs in fragments.

The histology is similar to that found in hepatitis C virus with dense lymphocytic portal infiltrate, constant piecemeal necrosis and fibrosis.

In more advanced disease, the changes observed are quite similar to those seen in autoimmune hepatitis, such as infiltration by inflammatory cells, piecemeal necrosis and fibrosis (scar tissue).

(formerly chronic active hepatitis) is any case of hepatitis occurring for more than 6 months with portal based inflammation, fibrosis, disruption of the terminal plate, and piecemeal necrosis.

Piecemeal necrosis of the liver is associated with a lymphocytic infiltrate into the adjacent parenchyma, and with destruction of individual hepatocytes along the edges of the portal tract.

Chronic hepatitis without piecemeal necrosis (or interface hepatitis) (formerly called chronic persistent hepatitis) is chronic hepatitis with no significant periportal necrosis or regeneration with a fairly dense mononuclear portal infiltrate.

When used in relation to the liver, piecemeal necrosis (also termed troxis necrosis, nibbling necrosis and interface necrosis) refers specifically to a loss and degeneration of hepatocytes at the lobular-portal-interface, producing a moth-eaten irregular appearance.