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The most well known picoline is vitamin B and its derivatives.
In 1868 he discovered pyridine and related organic compounds such as picoline through studies on the distillation of bone-oil and other animal matter.
Thus from the existing word picoline is derived pipecoline, and from lutidine is derived lupetidine; from phenidine and xanthoxylin are derived phenetidine and xanthoxyletin.
The unsubstituted pyridine ring degrades more rapidly than picoline, lutidine, chloropyridine, or aminopyridines, and a number of pyridine degraders have been shown to overproduce riboflavin in the presence of pyridine.
This process is carried out in a gas phase at 400-450 C. The product consists of a mixture of pyridine, simple methylated pyridines (picoline) and lutidine; its composition depends on the catalyst used and can be adapted to the needs of the manufacturer.
Similar pigments have been observed in quinoline degradation, also owing to transformation of metabolites, however the yellow pigments often reported in degradation of many pyridine solvents, such as unsubstituted pyridine or picoline, generally result from overproduction of riboflavin in the presence of these solvents.