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Its effect on skeletal muscle is greater than that of physostigmine.
The drug physostigmine is used to reverse the effect of the poisons.
As a result, a new and efficient synthesis of physostigmine was successfully developed.
He correctly predicted that physostigmine would become very important in the treatment of eye disorders.
"And physostigmine or whatever, that was the wife's medication?"
A specific antagonist is physostigmine which combines a peripheral and a central action.
Then, 19 is converted to esermethole 20, an intermediate in the synthesis of physostigmine.
Consequently, the first synthesis of physostigmine was completed.
More recently, physostigmine has been used to improve the memory of Alzheimer's patients due to its potent anticholinesterase activity.
The main goal of Julian's physostigmine synthesis was to get the intermediate key compound, l-eseroline 10.
The first total synthesis of physostigmine was achieved by Julian and Piki in 1935.
But physostigmine is a nasty drug.
If available, the muscle paralysis can be reversed by administration of a cholinesterase inhibitor such as physostigmine.
Toxicity reactions in animals, sometimes called larkspur toxicosis, can be treated with physostigmine.
House overdoses on physostigmine, a medication against Alzheimer's disease, and his mind flashes back to the bus scene before the accident.
However, effects from a single intramuscular injection of physostigmine last only about 60 minutes, necessitating frequent re-dosing.
The specific antidote for dimenhydrinate poisoning is physostigmine, usually given by IV in a hospital.
A typical representative of this group is physostigmine, which was isolated by Jobst and Hesse in 1864.
The antidote to atropine is physostigmine or pilocarpine.
When Julian completed his synthesis, the melting point matched the correct one for natural physostigmine from the calabar bean.
His death was the result of an overdose of physostigmine -- more usually known as eserine."
The Julian physostigmine synthesis was started from phenacetin 1 because 1 was inexpensive.
Emetogenic drugs commonly used in anaesthesia include nitrous oxide, physostigmine and opioids.
Moreover, the sodium bisulfite in commercially available preparations of physostigmine may cause life-threatening allergic responses.
"Something called physostigmine.