The Appel reaction begins with the formation of the phosphonium salt 2.

The phosphonium salts have been traditionally used for peptide synthesis.

The phosphonium acetate group does not have an impact on the subsequent Wittig reaction.

The phosphonium structure is converted to phosphine oxide as the result of this reaction.

They also are derived from phosphonium salts, but by deprotonation not alkylation.

Organic phosphonium salts are common reagents in the laboratory.

The phosphonium salt is a stable compound which can often be purified by recrystallisation from ethanol.

A phosphonium ylide can be prepared rather straightforwardly.

PPh combines with most alkyl halides to give phosphonium salts.

It is the phosphonium salt that undergoes the sulfonation:

Another common route to phosphine oxides is the thermolysis of phosphonium hydroxides.

Phosphonium coupling is a chemical reaction in organic chemistry for organic synthesis.

This salt is deprotonated to the phosphonium ylide Methoxymethylenetriphenylphosphine 4 by phenyllithium.

Phosphonium betaines are intermediates in the Wittig reaction.

The hydride is lithium aluminium hydride and the leaving group a phosphonium salt.

For example, benzyl chloride gives the phosphonium salt:

It is also easily alkylated to give phosphonium derivatives RPMe.

Reaction with Tebbe's reagent and phosphonium ylides to alkenes.

To generate Wittig reagents via deprotonation of phosphonium salts.

His early work was the study of phosphonium and phosphine derivatives and allied ammonium compounds.

Phosphonium is an ion.

Unlike phosphonium ylides, the dialkylphosphate salt byproduct is easily removed by aqueous extraction.

Their nucleophilicity is evidence by their reactions with alkyl halides to phosphonium salts.

An typical reaction involves triphenylphosphine with bromine to give bromotriphenyl phosphonium bromide:

Recently, besides their novel uses in phosphonium coupling, they have also found similar utilities in certain cross coupling reactions.