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Phenmetrazine was taken by The Beatles early in their career.
Phenmetrazine was introduced into clinical use in 1954 in Europe.
More recently phenmetrazine has continued to be abused around the world, in countries such as South Korea.
Phendimetrazine can essentially be thought of as an extended release and less abusable version of phenmetrazine.
At first, Preludin tablets were smuggled, but soon the smugglers started bringing in raw phenmetrazine powder.
Phendimetrazine functions as a prodrug to phenmetrazine, and approximately 30% of any given oral dose is converted into it.
It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past.
It is a derivative of phenmetrazine and may function as a prodrug to it similarly to phendimetrazine.
In clinical use, phenmetrazine produces less nervousness, hyperexcitability, euphoria and insomnia than drugs of the amphetamine family.
When stimulant use first became prevalent in Sweden in the 1950s, phenmetrazine was preferred to amphetamine and methamphetamine by users.
It is the 5-ketone derivative of phenmetrazine and would similarly be expected to produce psychostimulant effects, though pharmacological data is lacking.
At the time of the shooting Ruby said he was taking phenmetrazine, a central nervous system (CNS) stimulant.
Phendimetrazine (phenmetrazine)
In a study of the effectiveness on weight loss between phenmetrazine and dextroamphetamine, phenmetrazine was found to be slightly more effective.
Unlike phenmetrazine, ethcathinone (and therefore amfepramone as well) are mostly selective as noradrenaline releasing agents.
Part III dealt with "controlled" drugs such as amphetamine, methaqualone, and phenmetrazine, which have legitimate medical uses.
As anorectics in the treatment of obesity - e.g., amphetamine, phentermine, benzphetamine, phenmetrazine, aminorex.
Phenmetrazine was first patented in Germany in 1952 by Boehringer-Ingelheim, with some pharmacological data published in 1954.
It is the N-demethylated and cis-configured analogue of phendimetrazine as well as the cis-configured stereoisomer of phenmetrazine.
In the autobiographical novel "Rush" by Kim Wozencraft, intravenous phenmetrazine is described as the most euphoric and pro-sexual of the stimulants the author used.
Olmerová began to use phenmetrazine in combination with alcohol - she sought psychiatric help but her use of alcohol and drugs would continue to dog her career.
In addition, along with phenmetrazine, it is believed to be one of the active metabolites of phendimetrazine, which itself is inactive and behaves merely as a prodrug.
It was initially replaced by its analogue phendimetrazine which functions as a prodrug to phenmetrazine, but now it is rarely prescribed, due to concerns of abuse and addiction.
Its structure incorporates the backbone of amphetamine, the prototypical CNS stimulant which, like phenmetrazine, is a releasing agent of dopamine and norepinephrine.
In trials performed on rats, it has been found that after subcutaneous administration of phenmetrazine, both optical isomers are equally effective in reducing food intake, but in oral administration the levo isomer is more effective.