periportal

It is also known as the "periportal space of Mall".

Zone 1 (periportal) occurs in phosphorus poisoning or eclampsia.

The presence of these megaloschizonts was hypothesized to have caused periportal hepatitis and fibrosis.

Periportal fibrosis and cirrhosis is not uncommon.

Liver biopsy will show abundant PAS-positive globules within periportal hepatocytes.

As the liver appears to be the main site of this process, downstream liver cells suffer ischemia, leading to periportal necrosis.

During cholestasis, periportal hepatocytes have been shown to express integrins normally associated with bile duct epithelium.

Longer-term survivors frequently develop portal hypertension, esophageal varices, and hypersplenism from periportal fibrosis.

The ring of hepatocytes abutting the connective tissue of the triad is called the periportal limiting plate.

A few granules of copper-associated protein were deposited in periportal hepatocytes indicating an element of chronic cholestasis.

Intracellular and canalicular cholestasis, as well as periportal ductular proliferation always accompanied these cellular changes as the disease progressed.

Chronic hepatitis with piecemeal (periportal) necrosis (or interface hepatitis) with or without fibrosis.

There were large amounts of microvesicular fat, areas of intrahepatic cholestasis, balloon degeneration of hepatocytes, and periportal fibrosis.

Glutaminase is expressed in periportal hepatocytes, where it generates NH (ammonia) for urea synthesis, as does glutamate dehydrogenase.

Stage 2 - Periportal Stage: Enlarged triads; periportal fibrosis and/or inflammation.

Firstly, the presence of a cavernous transformation or 'cavernoma' represents the development of multiple periportal collateral channels in order to bypass the obstruction within the portal vein.

Fibrosis was variable, ranging from subtle, thin periportal and perisinusoidal collagen fibres to diffuse periportal and panlobular pericellular fibrosis (Fig 3).

The transhepatic parenchymal tract was subsequently dilated wth an 8 mm angioplasty balloon; on initial inflation a characteristic sharp waste related to the dense periportal fibrosis was seen (Fig 3).

The periportal zone I is nearest to the entering vascular supply and receives the most oxygenated blood, making it least sensitive to ischemic injury while making it very susceptible to viral hepatitis.

Using antibodies directed against specific integrins, the authors show de novo expression of specific integrin receptor patterns by hepatocytes during inflammatory liver disease and in periportal hepatocytes during cholestasis (see above).

Chronic hepatitis without piecemeal necrosis (or interface hepatitis) (formerly called chronic persistent hepatitis) is chronic hepatitis with no significant periportal necrosis or regeneration with a fairly dense mononuclear portal infiltrate.

The activity of argininosuccinate synthetase in arginine synthesis occurs largely in at the outer mitochondrial membrane of periportal liver cells as part of the urea cycle, with some activity occurring in cortical kidney cells.

De novo expression of specific integrins with attachment affinity for type I collagen, laminin, and fibronectin has also been documented in chronic hepatitis B in both lobular and periportal hepatocytes, particularly in those cells in close proximity to lymphocyte infiltrates.

This hypothesis has been examined in several studies looking at the PiZ phenotype and periportal α 1 AT granules in patients and controls, and no evidence to support involvement of α 1 AT in genetic predisposition has been found.

Some of the deposited eggs reach the outside environment by passing through the wall of the intestine; the rest are swept into the circulation and are filtered out in the periportal tracts of the liver resulting in periportal fibrosis.