Its primary input is the perforant path from the superficial layers of entorhinal cortex.

Most external input comes from the adjoining entorhinal cortex, via the axons of the so-called perforant path.

Here the perforant path fibers form synapses onto the distal, apical dendrites of pyramidal cells.

Thus, the perforant path establishes the EC as the main "interface" between the hippocampus and other parts of the cerebral cortex.

The experiment described was conducted on the synapse between the perforant path and dentate gyrus in the hippocampi of anaesthetised rabbits.

The entorhinal cortex transmits its signals from the parahippocampal gyrus to the dentate gyrus via granule cell fibers known collectively as the perforant path.

In CA3, it is the perforant path projection from the entorhinal cortical cells that provides synaptic input to the most distal dendrites of the pyramidal cells.

The perforant pathway is divided into the medial and lateral perforant paths, generated, respectively, at the medial and lateral portions of the entorhinal cortex.

The mossy fiber pathway terminates in stratum lucidum while the perforant path passes through stratum lacunosum and terminates in stratum moleculare.

Region CA3 receives input along the mossy fibers from granule cells in the dentate gyrus (DG) and from projection cells in entorhinal cortex along the perforant path.

Anatomically, in the rat, it is best defined as the strip of cells that receive perforant path input from EC layer II but do not receive mossy fiber connections from DG.

The first such synapses to be identified in the mammalian brain were the excitatory connections made by perforant path fibres onto granule cells of the hippocampus, a cortical structure required for the formation of conscious memories in man.

It contains the perforant path (the main input to the hippocampus, extending from the entorhinal cortex to dentate gyrus), along with several other fibers interconnecting the entorhinal cortex, parahippocampal gyrus, and associated areas.

They were able to show a burst of tetanic (100 Hz) stimulus on perforant path fibres led to a dramatic and long-lasting augmentation in the post-synaptic response of cells onto which these fibres synapse in the dendate gyrus.

The medial perforant path synapses onto the proximal dendritic area of the granule cells, whereas the lateral perforant path does so onto the distal dendrites of these same cells.

In a study published in Nature Neuroscience he showed that, in both insulin-deficient rats and insulin-resistant mice, diabetes impairs hippocampus-dependent memory, perforant path synaptic plasticity and adult neurogenesis, and the adrenal steroid corticosterone contributes to these adverse effects.

Perforant path input from EC layer II enters the dentate gyrus and is relayed to region CA3 (and to mossy cells, located in the hilus of the dentate gyrus, which then send information to distant portions of the dentate gyrus where the cycle is repeated).