Paroxysmal cold hemoglobinuria (rare)

In 1904, Donath and Landsteiner suggested a serum factor was responsible for hemolysis in paroxysmal cold hemoglobinuria.

Paroxysmal cold hemoglobinuria (PCH) is a rare type of anemia characterized by the premature destruction of healthy red blood cells by autoantibodies.

AIHA is classified as either warm autoimmune hemolytic anemia or cold autoimmune hemolytic anemia, which includes cold agglutinin disease, and paroxysmal cold hemoglobinuria.

PCH Donath-Landsteiner hemolytic anemia Donath-Landsteiner syndrome immune hemolytic anemia, paroxysmal cold None A majority of cases of paroxysmal cold hemoglobinuria (PCH) recorded in the early medical literature were associated with late syphilis or congenital syphilis.