paraoxonase

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members.

Reports of the geographic differences in population frequencies of paraoxonase activity and genetic analysis led to uncovering the genetic polymorphism.

Other enzymes that have antioxidant properties (though this is not their primary role) include paraoxonase, glutathione-S transferases, and aldehyde dehydrogenases.

GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood.

The enzyme paraoxonase 1 (PON1) detoxifies chlorpyrifos oxon, the more toxic metabolite of chlorpyrifos, via hydrolysis.

PPAR-gamma activates the PON1 gene, increasing synthesis and release of paraoxonase 1 from the liver, reducing atherosclerosis.

Patients with Hp2-2 or Hp1-1 were evaluated for baseline levels of plasma and urinary isoprostanes, CRP, myeloperoxidase, paraoxonase and other markers of inflammation or oxidative stress.

Recently, he determined the structures of acid-β-glucosidase, a protein defective in Gaucher disease, paving the way to novel therapeutic approaches, and of paraoxonase, a protein relevant to treatment of atherosclerosis.

A team at Manchester Royal Infirmary are verifying the results of an earlier study which reported finding that ill Gulf veterans have a lower activity of the enzyme paraoxonase which metabolises organophosphates.