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This may be fatal, if left untreated as is in a case of pancarditis.
Of the most serious complications is pancarditis, or inflammation of all three heart tissues.
Pancarditis, which includes pericardial and myocardial fibrosis, with or without endocardial fibroelastosis.
In acute rheumatic fever, these lesions can be found in any layer of the heart and is hence called pancarditis.
ARF is often clinically diagnosed based on Jones Criteria, which include: pancarditis, migratory polyarthritis of large joints, subcutaneous nodules, erythema marginatum, and sydenham chorea (involuntary, purposeless movement).