novobiocin

It is resistant to novobiocin.

Presently ciprofloxacin, minocycline, trimethoprim-sulfamethoxazole, rifampin and novobiocin are being considered good alternatives.

As a second test of the effect of selection on the outer membrane, I measured the resistance to the antibiotic novobiocin of each population.

Again, if selection had increased membrane permeability, sensitivity to novobiocin might have increased relative to the partially resistant ancestor.

The aminocoumarins (including novobiocin).

The molecular basis of action of novobiocin, and other related drugs clorobiocin and coumermycin A1 has been examined.

The final component of novobiocin is the sugar derivative L-noviose, known as ring C, which is derived from glucose-1-phosphate.

Rings A, B, and C are coupled together and modified to give the finished novobiocin molecule.

Experiments are underway to establish the mechanism that links adaptation, increased membrane permeability, and increased novobiocin sensitivity.

It is resistant to novobiocin, bacitracin, vibriostatic agent O/129, lysozyme, metronidazole and optochin.

Assays were conducted by distributing approximately 250 cells on LB plates containing 400 μg/ml novobiocin.

Most, if not all, strains are susceptible to penicillin, erythromycin, and novobiocin, but a divergent strain, S. hominis subsp.

The combined resistance to novobiocin and oxacillin is hypothesized to have originated from a simultaneous introduction of genes controlling the resistance to the two.

Most populations completely lost the ability to grow in the presence of novobiocin, which suggests an increase in membrane permeability [ 33 ] .

Occasional strains are resistant to novobiocin and may be confused with other resistant species (e.g. S. saprophyticus.)

Poisons of type II topoisomerases include etoposide, novobiocin, quinolones (including ciprofloxacin), and teniposide.

Bacterial DNA gyrase is the target of many antibiotics, including nalidixic acid, novobiocin, and ciprofloxacin.

This strain was named so because of its unique resistance to novobiocin and its failure to produce acid aerobically from trehalose and glucosamine.

It is sensitive to novobiocin, providing an important test to distinguish it from Staphylococcus saprophyticus, which is coagulase-negative, as well, but novobiocin-resistant.

This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis and novobiocin biosynthesis.

Other mechanisms include de novo synthesis of a coumarin-resistant gyrase B subunit by the novobiocin producer S. sphaeroides .

S. xylosus is normally sensitive to fleroxacin, methicillin, penicillin, teicoplanin, tetracycline and resistant erythromycin and novobiocin.

This methylation allows NovN to carbamylate the 3 position of the sugar as shown in Fig. 4 completing the biosynthesis of novobiocin.

The potency of novobiocin is considerably higher than that of the fluoroquinolones that also target DNA gyrase, but at a different site on the enzyme.

They identified 23 putative open reading frames (ORFs) and more than 11 other ORFs that may play a role in novobiocin biosynthesis.