To overcome imatinib resistance and to increase responsiveness to TK inhibitors, two novel agents were later developed.

Peptide antibiotics, including protegrins, are currently under consideration as novel agents for treating pulmonary infections in CF patients.

The order has expanded considerably during recent years due to the discovery of many novel agents that were found to be phylogenetically diverse from already known mononegaviruses.

D. Neurotherapeutics in Multiple Sclerosis: Novel Agents and Emerging Treatment Strategies.

Novel agents like thalidomide, lenalidomide and bortezomib have been recently used, alone or in combination with conventional chemotherapeutics like melphalan or cyclophosphamide.

For patients with technically unresectable tumors, clinical trials evaluating novel agents in combination with chemotherapy or chemoradiation therapy (RTOG-PA-0020 is one example).

Combined modality treatment of tumors of the CNS and thorax, as well as pediatric neoplasms: integrating systemic chemotherapy and novel agents, including personalized medicine approaches.

The Developmental Therapeutics Research Program at Yale Cancer Center has been successful in discovering a wide range of novel agents, many of which are now undergoing pre-clinical and clinical testing.

He appears as the character named Jamal Ramlawi in the spy novel Agents of Innocence by David Ignatius, a thinly disguised account of his recruitment by the CIA.

Because novel FR-targeted therapies are now being tested clinically, having the ability to screen patients for FR-positive disease could certainly increase the efficiency of and decrease the time for clinical investigations of these novel agents.

B. Hager, W. S. L. Strauss, and H. Falk: Cationic Hypericin Derivatives as Novel Agents with Photobactericidal Activity: Synthesis and Photodynamic Inactivation of Propionibacterium acnes.

Antivascular agents are similar to colchicine and bind to the colchicine binding site on β-tubulin so development of novel agents acting with colchicine binding site (which is not used by any of currently approved drugs) seems to be a promising approach.