These patients were looked at specifically due to their increased sensitivity to nociceptive stimuli.

The adequate stimuli of nociceptors are termed nociceptive stimuli.

A nociceptive stimulus is defined as "an actually or potentially tissue damaging event transduced and encoded by nociceptors."

Hyperpathia is a clinical symptom of certain neurological disorders wherein nociceptive stimuli evoke exaggerated levels of pain.

The ventrobasal complex ("'VB"') is a relay nucleus of the thalamus for nociceptive stimuli received from nociceptive nerves.

The VB serves as the main relay for nociceptive stimuli and the modulation of that stimuli to the primary somatosensory cortex.

This study showed that the primary and secondary sensorimotor cortex, posterior insula, and lateral thalamus are involved in processing aspects of nociceptive stimuli such as location and intensity.

Regarding nociceptive stimulation, spatial summation is the ability to integrate painful input from large areas while temporal summation refers to the ability of integrating repetitive nociceptive stimuli.

Modern research has gathered considerable amounts of evidence that support the theory that pain is not only a physical phenomena but rather a biopsychosocial phenomena, encompassing culture, nociceptive stimuli, and the environment in the experience and perception of pain.

Other uses of MAC include MAC-BAR (1.7-2.0 MAC), which is the concentration required to block autonomic reflexes to nociceptive stimuli, and MAC-awake (0.3-0.5 MAC), the concentration required to block voluntary reflexes and control perceptive awareness.