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We determined the molecular lesion of the cn 1allele to be a 1,832 bp deletion relative to wild type.
Failure to correct molecular lesions in cells that form gametes can introduce mutations into the genomes of the offspring and thus influence the rate of evolution.
Pyrimidine dimers are molecular lesions formed from thymine or cytosine bases in DNA via photochemical reactions.
In human cells, both normal metabolic activities and environmental factors such as UV light can cause DNA damage, resulting in as many as 1 million individual molecular lesions per cell per day.
Alex Matter was announced the recipient of the 8th Annual Szent-Györgyi Prize for Progress in Cancer Research for his contributions to the development of the first drug specifically targeting a molecular lesion in cancer.
A molecular lesion is damage to the structure of a biological molecule such as DNA, enzymes, or proteins that results in reduction or absence of normal function or, in rare cases, the gain of a new function.
Although large-scale chemical mutagenesis screens were getting underway in several zebrafish labs at the time (those of Mark Fishman in Boston, and Christiane Nusslein-Volhard in Tubingen, Germany), there were concerns in the community at the time that identifying the molecular lesions using positional cloning methods would be inefficient.