mitogenic factor

Studies on purified rat sciatic nerve Schwann cells have shown that proliferation in vitro depends on mitogenic factors.

Leptin is a pro-angiogenic, pro-inflammatory and mitogenic factor, the actions of which are reinforced through crosstalk with IL-1 family cytokines in cancer.

The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines.

The supernatant contains a mitogenic factor, a mitosis promoting factor, that is characterized heat and trypsin sensitivity, both of which characterize it as a peptide.

Estrogen is well-established as a mitogenic factor implicated in the tumorigenesis and progression of breast cancer via its binding to the estrogen receptor alpha (ERα).

Treatment of Schwann cells with the collected supernatant shows that it is a mitogenic factor and thus plays an important role in the proliferation of Schwann cells.

Nevertheless, it seems that colorectal tumours are unlikely to make a consistently important contribution to circulating plasma gastrin, although raised postprandial gastrin of antral origin may be significant as a mitogenic factor in promoting tumour growth.

Thus, the proliferation stage of CFA may depend to large extent on mitogenic factors produced by the epithelium, including transforming growth factor, tumour necrosis factor, and ET-1, acting synergistically to stimulate fibroblast growth and extracellular production.

Indirectly, nicotine increases cholinergic signalling (and adrenergic signalling in the case of colon cancer), thereby impeding apoptosis (programmed cell death), promoting tumor growth, and activating growth factors and cellular mitogenic factors such as 5-LOX, and EGF.