megestrol acetate

The most common side effect of megestrol acetate is weight gain.

Megestrol acetate is frequently used as an appetite stimulant.

Megestrol acetate is the lead drug of this class for the management of cachexia.

Studies of dronabinol alone or with megestrol acetate have not shown superior benefit in promoting weight gain and appetite.

Megestrol acetate should not be used in pregnancy under any circumstance as it crosses the placenta and malignantly affects the fetus.

Unlike the case of the AR, megestrol acetate has no significant affinity for the ER.

She was started on low-dose hydrocortisone for her adrenal insufficiency and megestrol acetate to increase her appetite.

The steroidal antiandrogen megestrol acetate suppresses androgen production incompletely and is generally not used as initial therapy.

High-dose megestrol acetate is used to treat anorexia, cachexia, and AIDS-related wasting.

Megestrol acetate acts predominantly as a potent agonist of the progesterone receptor (PR) to exert its effects.

Its acylated derivative megestrol acetate is also a progestogen, which, in contrast to megestrol itself, has been extensively used as a pharmaceutical drug.

DRUGS - Two are effective: megestrol acetate (Megace) and clonidine (Catapres).

In addition to its use in humans, megestrol acetate has been used extensively in veterinary medicine in the treatment of medical conditions in cats and dogs.

Furthermore, unlike conventional antiandrogens like cyproterone and flutamide, there is relatively little risk of indirectly-mediated estrogenic side effects (e.g., gynecomastia) with megestrol acetate.

Other hormone therapies may include the use of medicines such as megestrol acetate, estrogen, ketoconazole, aminoglutethimide combined with hydrocortisone, and corticosteroids (prednisone, dexamethasone, and hydrocortisone).

Destructive lesions (e.g. neoplasia, inflammation) in the pituitary gland or hypothalamus and chronic administration of exogenous glucocorticoids or megestrol acetate (cats) are the most common causes.

Though sometimes referred to simply as megestrol, it is important to clarify that megestrol acetate is not the same as megestrol, which is a closely related but different compound.

Megestrol acetate is used mainly as an appetite stimulant in a variety of conditions and as an antineoplastic agent in the treatment of breast, endometrial, and prostate cancers.

Progestins (progesterone-like drugs) such as megestrol acetate and medroxyprogesterone acetate have been used for the treatment of hormone-responsive, advanced breast cancer, endometrial cancer, and prostate cancer.

Ulutin HC, Arpaci F, Pak Y: Megestrol acetate for cachexia and anorexia in advanced non-small cell lung cancer: a randomized study comparing two different doses.

Accordingly, manifestations of its glucocorticoid properties, including symptoms of Cushing's syndrome, steroid diabetes, and adrenal insufficiency, have been reported with the use of megestrol acetate in the medical literature, albeit sporadically.

McQuellon RP, Moose DB, Russell GB, et al.: Supportive use of megestrol acetate (Megace) with head/neck and lung cancer patients receiving radiation therapy.

Buzdar A, Douma J, Davidson N, et al.: Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate.