Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis where degenerative changes occur at the dermoepidermal junction, with lymphophatic inflammation at the epidermis and dermis.

Liquefactive necrosis can also occur in the lung.

For unclear reasons, hypoxic death of cells within the central nervous system also results in liquefactive necrosis.

Liquefactive necrosis in chronic abscesses may get calcified.

The brain tissue will undergo liquefactive necrosis, and a rim of gliosis will form around the damaged area.

Wet gangrene is coagulative necrosis progressing to liquefactive necrosis.

One exception to coagulative necrosis is the brain, which undergoes liquefactive necrosis in response to infarction.

Liquefactive necrosis (or colliquative necrosis) is a type of necrosis which results in a transformation of the tissue into a liquid viscous mass.

Liquefactive necrosis (or colliquative necrosis), in contrast to coagulative necrosis, is characterized by the digestion of dead cells to form a viscous liquid mass.

In liquefactive necrosis, the affected cell is completely digested by hydrolytic enzymes, resulting in a soft, circumscribed lesion consisting of pus and the fluid remains of necrotic tissue.

It is important to note that while ischemia in most tissues of the body will cause coagulative necrosis, in the central nervous system ischemia causes liquefactive necrosis as there is very little structural framework in neural tissue.

When the hilar lymph node for instance is infected with tuberculosis and leads to caseous necrosis, its gross appearance can be a cheesy tan to white, which is why this type of necrosis is often depicted as a combination of both coagulative and liquefactive necrosis.