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The isochore theory became one of the most useful theories in molecular evolution for many years.
The main predictions of the isochore theory are that:
An isochore map displays lines of equal thickness in a layer where the thicknesses are measured vertically.
Isochore may refer to:
A case that has received much attention is in regard to genomic GC-content and the origin of isochore.
Despite the interest in the early years in the isochore model, in recent years, the theory's methodology, terminology, and predictions have been challenged.
An isopach map is similar to an isochore map, but these terms actually describe different methods of displaying thickness variations within a layer.
The isochore model was proposed by Bernardi and colleagues to explain the observed non-uniformity of genomic fragments in the genome.
The theory proposed that isochore's composition varied markedly between "warm-blooded" (homeotherm) vertebrates and "cold-blooded" (poikilotherm) vertebrates and later became known as the isochore theory.
Thus, an isochore and isopach map are the same only when both the top and bottom surfaces of the layer shown are horizontal (i.e., the true stratigraphic and true vertical thicknesses are the same).
When the layer shown is inclined, as is usually the case, the thicknesses displayed in an isochore map of the layer will be greater than the thicknesses displayed in an isopach map of the same layer.
The isochore theory was the first to identify the nonuniformity of nucleotide composition within vertebrate genomes and predict that the genome of "warm-blooded" vertebrates such as mammals and birds are mosaic of isochores (Bernardi et al. 1985).
Unfortunately the terms isopach and isochore are widely confused, and many times maps of True Vertical Thickness (TVT), which by definition are isochore maps, are incorrectly labeled isopach maps.
Heat flows into the loop through the top isotherm and the left isochore, and some of this heat flows back out through the bottom isotherm and the right isochore, but most of the heat flow is through the pair of isotherms.