The cell surface form of the invariant chain is known as CD74.

The signal for endosomal targeting resides in the cytoplasmic tail of the invariant chain.

The down regulation of the invariant chain (Ii) becomes important when considering the two pathways by which antigens are presented by cells.

Path PDFs for translation invariant chains are mono-peaked.

The invariant chain is then broken down in stages, leaving only a small fragment called CLIP which still blocks the peptide binding cleft.

The invariant chain also facilitates MHC class II's export from the ER in a vesicle.

The invariant chain (Abbreviated Ii) is a polypeptide involved in the formation and transport of MHC class II protein.

During MHC II assembly, invariant chain complexes with the MHC II complex.

CD74, the MHC class II-associated Invariant Chain, regulates the motility and in vivo migration of dendritic cells.

Path PDF for translation invariant chains mostly contribute to the Green's function in the vicinity of its peak, but this behavior is believed to characterize heterogeneous chains as well.

During synthesis of class II MHC in the endoplasmic reticulum, the α and β chains are produced and complexed with a special polypeptide known as the invariant chain.

The invariant chain also facilitates the export of class II MHC from the ER to the golgi, followed by fusion with a late endosome containing endocytosed, degraded proteins.

Cathepsin L is active at neutral pH by associating with a p41 splice variant of the MHC class II-associated invariant chain which is strongly expressed in EPCs.

In a special endosome called the MHC II compartment, cathepsin S cleaves the invariant chain, leaving CLIP bound to the MHC II complex.

This technique has not been used in vivo, but rather involves injection of tumor cells which have been transfected to express MHC class II molecules, in addition to suppression of the invariant chain (Ii, see below) through antisense technology.

HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene.

The nascent MHC class II protein in the rough ER has its peptide-binding cleft blocked by the invariant chain (Ii; a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway.

These antigen proteins are prevented from binding to MHC class II molecules by a protein known as the invariant chain or Ii, which, in a normal cell, remains bound to the MHC class II molecule until leaving the ER.

CLIP or Class II-associated invariant chain peptide is the part of the invariant chain (li) that binds MHC class II groove and remains there until the MHC receptor is fully assembled.