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A clinical error where an intravenous preparation is given intrathecally will result in over administration.
Only preservative-free local anesthetic agents may be injected intrathecally.
Bier injected 15 mg of cocaine intrathecally, which was sufficient to allow him to perform the operation.
Folinic acid should not be administered intrathecally.
A catheter was inserted intrathecally in the subarachnoid space to the level of the fourth or fifth cervical segment.
It should also never be administered intrathecally (into the spinal canal), as this will cause extensive damage to the nervous system and may lead to death.
CNS prophylaxis (usually with four to six injections of methotrexate intrathecally) is recommended for all patients.
It can be administered intramuscularly, intravenously, intrathecally, intranasally, buccally, or orally.
How to use baclofen IT This medication is injected only into the space around the spinal cord (intrathecally).
Baclofen can be administered either orally or intrathecally (directly into the cerebral spinal fluid) using a pump implanted under the skin.
Fentanyl is sometimes given intrathecally as part of spinal anesthesia or epidurally for epidural anesthesia and analgesia.
When baclofen is administered intrathecally, it may cause CNS depression accompanied with cardiovascular collapse and respiratory failure.
Lumbar punctures may also be done to inject medications into the cerebrospinal fluid ("intrathecally"), particularly for spinal anesthesia or chemotherapy.
CSE in labouring women is associated with more pruritus if fentanyl (25μg) is given intrathecally, than low-dose epidural analgesia.
Lately iatrogenic arachnoiditis has been attributed to misplaced Epidural Steroid Injection therapy when accidentally administered intrathecally.
Opioid medications may be administered orally, by injection, via nasal mucosa or oral mucosa, rectally, transdermally, intravenously, epidurally and intrathecally.
Steroid injections, administered either intrathecally or epidurally have been linked as a cause of the disease, therefore they are generally discouraged as a treatment and may even worsen the condition.
Doctors requested to deliver hydroxy-propyl-beta-cyclodextrin intrathecally and directly into the central nervous system of the twins in an attempt to arrest neurodegeneration and deliver the compound across the blood-brain barrier.
Phase 3 of the EUS EMG (recorded during the falling phase of a bladder contraction) was not affected by clozapine administered intrathecally (Fig 6C).
Due to the profound side effects or lack of efficacy when delivered through more common routes, such as orally or intravenously, ziconotide must be administered intrathecally (i.e. directly into the spinal fluid).
Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (as in diskography of the spine) and intraabdominally - just about any body cavity or potential space.
With early diagnosis and treatment consisting of daily injections of copper histidine intraperitoneally and intrathecally to the central nervous system, some of the severe neurological problems may be avoided and survival prolonged.
Drugs given intrathecally often have to be made up specially by a pharmacist or technician because they cannot contain any preservative or other potentially harmful inactive ingredients that are sometimes found in standard injectable drug preparations.
In order to find out the relationship between GABA, NMDA, and SP, MK-801 was administered intrathecally to determine the effect on muscimol potentiation of SP hyperalgesia.
Discussion In the present experiments, central application of clozapine (intrathecally over the L6/S1 spinal segments or intracerebroventricularly into the lateral ventricle) resulted in a number of changes in the urodynamic parameters of anesthetized rats.