interdigitating dendritic cell

Interdigitating dendritic cell sarcoma is a form of malignant histiocytosis affecting dendritic cells.

Most S-100 protein + interdigitating dendritic cells were clustered in the interfollicular zones of Peyer's patches.

Viruses pre-exposed to non-neutralizing complement system have also been found to enhance infections in interdigitating dendritic cells (iDCs).

Interdigitating dendritic cells are characterised by a highly irregular surface, strong constitutive expression of major histocompatibility complex class II molecules, and low phagocytic ability.

Interdigitating dendritic cells are therefore believed to function primarily as antigen presenting cells, although they are often included in the generic term 'macrophages'.

The monoclonal antibodies 25F9 and RFD7 bind to mature human tissue macrophages whereas RFD1 identifies interdigitating dendritic cells.

Also subepithelial and interfollicular CD68 interdigitating dendritic cells in Peyer's patches (recognised by antibody to S-100 protein) were usually unreactive with L1 antibody.

By the time the dendritic cells appear in peripheral lymph, however, they have become irreversibly differentiated and may terminate as interdigitating dendritic cells in T cell zones of organised lymphoid tissue.

Wright et al reported that particular antigens, after initial phagocytosis, may be reprocessed for presentation to T cells, and Guides et al proposed a functional complementation between mononuclear phagocytes and interdigitating dendritic cells.

A particular difference between murine class II-expressing macrophages and interdigitating dendritic cells seems to be that only the second subset is capable of triggering resting T cells, whereas the first needs primed T cells to induce immune responses.

The abundant subepithelial and intrafollicular CD68 + macrophages seen in Peyer's patches were all HLA-DR positive (Fig 2B), as were the S-100 protein + interdigitating dendritic cells sometimes found beneath the follicle associated epithelium (Fig 1A).