insulitis

Due to its high toxicity to beta cells, in scientific researches, streptozotocin has also been long used for inducing insulitis and diabetes on experimental animals.

Diabetes develops in NOD mice as a result of insulitis, a leukocytic infiltrate of the pancreatic islets.

If the stress on β cells that leads to type II diabetes is a progressively increasing demand (insulin resistance), the stress that leads to type I diabetes is arguably a progressively diminishing reserve (insulitis).