At the same time, the inner enamel epithelial cells change in shape from cuboidal to columnar.

This layer is first seen during the bell stage, in which these inner enamel epithelium will differentiate into ameloblasts.

Researchers believe that the odontoblasts would not form if it were not for the changes occurring in the inner enamel epithelium.

The rim of the dental organ where the outer and inner enamel epithelium join is called the cervical loop.

This layer, along with the inner enamel epithelium, is responsible for the tooth enamel formation.

Additionally, the junction between the dental papilla and inner enamel epithelium determines the crown shape of a tooth.

The cells between the inner enamel epithelium and the stellate reticulum form a layer known as the stratum intermedium.

The columnar cells of the enamel organ adjacent to the dental papilla are known as inner enamel epithelium.

After dentin formation begins, the cells of the inner enamel epithelium secrete an organic matrix against the dentin.

They begin secreting an organic matrix around the area directly adjacent to the inner enamel epithelium, closest to the area of the future cusp of a tooth.

The parts of the enamel organ include the inner enamel epithelium, outer enamel epithelium, stratum intermedium, and the stellate reticulum.

A message is sent from the newly differentiated odontoblasts to the inner enamel epithelium (IEE), causing the epithelial cells to further differentiate into active secretory ameloblasts.

In tooth development, the enamel knot is a localization of cells on an enamel organ that appear thickened in the center of the inner enamel epithelium.

As the changes to the inner enamel epithelium and the formation of odontoblasts continue from the tips of the cusps, the odontoblasts secrete a substance, an organic matrix, into their immediate surrounding.

These tissues are enveloped by a basal layer of epithelium known on the outside of the tooth as outer enamel epithelium and on the inside as inner enamel epithelium.

The inner enamel epithelium, also known as the internal enamel epithelium, is a layer of columnar cells located on the rim nearest the dental papilla of the enamel organ in a developing tooth.

In prior stages, all of the inner enamel epithelium cells were dividing to increase the overall size of the tooth bud, but rapid dividing, called mitosis, stops during the crown stage at the location where the cusps of the teeth form.